Arsenal's Carabao Cup final defeat to Manchester City coupled with their FA Cup quarterfinal exit to Southampton ended their hopes of becoming the first side to win a quadruple.
Despite the setbacks, the Gunners remain firmly in line to create history this season. And the club aren't the only club in Europe that could do so this season.
ESPN breaks it all down.
How Arsenal can write themselves into history
Arsenal ousted Bayer Leverkusen in the round of 16 to set up a quarterfinal showdown against Sporting CP, who they overcame 1-0 across both legs.
Mikel Arteta's side are into their second-successive Champions League semifinal, and go into the second leg of their clash against Atlético Madrid with scores level at 1-1.
The women's side remain in the hunt for European glory too. Last season's winners knocked out their Women's Super League rivals Chelsea in the quarterfinals to seal a spot in the semifinals.
The holders registered a 2-1 win in the first leg of their semifinal tie against OL Lyonnes and will hope to finish the job in France.
If both sides do go all the way in their respective competitions, Arsenal could become the first-ever club to lift the men's and women's Champions League in a single season.
Have any clubs come close to achieving this?
Arsenal themselves came close last year -- Renee Slegers' side shocked Barcelona in the final to win the UWCL but the men's side fell short after being knocked out in the semifinals by Paris Saint-Germain.
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- Cool Arsenal ensure Chelsea's Champions League wait goes on
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Chelsea nearly did the double in 2021, when the men's and women's side reached the final. Thomas Tuchel's side beat Manchester City to win the second men's Champions League in their history but the women's team suffered a harrowing 4-0 defeat to Barcelona.
Which other clubs could win the men's and women's Champions League this year?
One of Barcelona and Bayern Munich could achieve the feat this season, with the two sides facing each other in the semifinals of the UWCL.
The sides played out a 1-1 draw in the first leg, leaving the tie hanging in the balance.
Barça thrashed fellow Liga F side Real Madrid 12-2 on aggregate in the quarterfinals while Bayern edged Manchester United 5-3 to reach this stage.
On the men's side. Barça were knocked out by Atlético Madrid, while Real Madrid were eliminated in a 6-4 thriller against Bayern Munich.
Bayern will face holders Paris Saint-Germain, who eliminated Liverpool with a commanding 4-0 victory.
