Dan Burn has been called up by England to replace Marc Guéhi, who has withdrawn with an injury.
England play Croatia at Wembley on Thursday, then world champions Spain on Sunday, in the Nations League.
Guéhi was substituted at half-time of Manchester City's defeat to Nottingham Forest in the Premier League at the weekend and has now been forced to pull out of Thomas Tuchel's squad.
Guéhi's run of featuring in 15 consecutive England matches will end, while Burn has been called up for the first time since the World Cup in the summer. The Newcastle United defender has the chance to add to his 11 caps as a replacement for Guéhi.
Burn played a crucial role as a late substitute at the World Cup as England saw out a tense victory against co-hosts Mexico amid the altitude of the Azteca Stadium.
Other centre-back options for the upcoming Nations League fixtures include Jarrad Branthwaite, Ezri Konsa and Jarell Quansah while Ben White is also included. Lewis Hall and Djed Spence are left-back options.
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