College football returns in full force in Week 1, with three top 25 games with a point spread of 10 or fewer: Clemson at No. 11 LSU (-10) in Baton Rouge, La., No. 9 Ole Miss (-6.5) vs. No. 24 Louisville in Nashville, Tenn., and SMU (-3) at Florida State in Tallahassee, Fla.
No. 1 Ohio State (vs. Ball State), No. 2 Oregon (vs. Boise State), No. 3 Georgia (vs. Tennessee State), No. 4 Notre Dame (vs. Wisconsin) and No. 5 Texas (vs. Texas State) are all favored by at least 20 points.
Indiana head coach Curt Cignetti and the defending champion Hoosiers begin their season ranked No. 6, and are 40.5-point favorites over North Texas in their opener in Bloomington, Ind.
Here's a closer look at the lines for all the teams in the top 25.
All times Eastern. Odds by DraftKings and subject to change.

Arkansas-Pine Bluff at No. 25 Missouri -55.5
Thursday, 8 p.m., SEC Network
Records: Arkansas-Pine Bluff 1-0; Missouri 0-0, 0-0 vs. AP Top 25
Opening Line: Missouri -54.5, O/U 60.5
Over/Under: 61.5 (O -120, U 100)
FPI Projection Missouri by 58.5 points with a >99% probability to win game outright

Idaho at No. 21 Utah -36.5
Thursday, 9 p.m., ESPNU
Records: Idaho 0-1; Utah 0-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Utah -32.5, O/U 56.5
Money line: Idaho (+5000); Utah (-100000)
Over/Under: 59.5 (O -108, U -112)
FPI Projection Utah by 31.1 points with a 97% probability to win game outright

UTEP at No. 10 Oklahoma -40.5
Friday, 8 p.m., SECN+
Records: UTEP 0-0, 0-0 vs. AP Top 25; Oklahoma 0-0, 0-0 vs. AP Top 25
Opening Line: Oklahoma -40.5, O/U 50.5
Over/Under: 51.5 (O -110, U -110)
FPI Projection Oklahoma by 38.8 points with a 99% probability to win game outright

No. 7 Miami -24.5 at Stanford
Friday, 9 p.m., ESPN
Records: Miami 0-0, 0-0 vs. AP Top 25; Stanford 1-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Miami -21.5, O/U 48.5
Money line: Miami (-3200); Stanford (+1400)
Over/Under: 48.5 (O 100, U -120)
FPI Projection Miami by 21.4 points with a 92% probability to win game outright

Fresno State at No. 14 USC -22.5
Friday, 9 p.m., FOX
Records: Fresno State 0-0, 0-0 vs. AP Top 25; USC 1-0, 0-0 vs. AP Top 25
Opening Line: USC -23.5, O/U 51.5
Money line: Fresno State (+1100); USC (-2100)
Over/Under: 51.5 (O -112, U -108)
FPI Projection USC by 17.2 points with a 88% probability to win game outright

North Texas at No. 6 Indiana -40.5
Saturday, Noon, FOX
Records: North Texas 0-0, 0-0 vs. AP Top 25; Indiana 0-0, 0-0 vs. AP Top 25
Opening Line: Indiana -40.5, O/U 55.5
Over/Under: 56.5 (O -112, U -108)
FPI Projection Indiana by 33.9 points with a 98% probability to win game outright

East Carolina at No. 13 Alabama -28.5
Saturday, Noon, ABC
Records: East Carolina 0-0, 0-0 vs. AP Top 25; Alabama 0-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Alabama -25.5, O/U 54.5
Money line: East Carolina (+2200); Alabama (-8000)
Over/Under: 52.5 (O -110, U -110)
FPI Projection Alabama by 24.4 points with a 95% probability to win game outright

Oregon State at No. 23 Houston -21
Saturday, Noon, ESPN, Disney+
Records: Oregon State 0-0, 0-0 vs. AP Top 25; Houston 0-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Houston -18.5, O/U 50.5
Money line: Oregon State (+950); Houston (-1650)
Over/Under: 49.5 (O -112, U -108)
FPI Projection Houston by 20.1 points with a 91% probability to win game outright

Ball State at No. 1 Ohio State -50.5
Saturday, 12:30 p.m., BTN
Records: Ball State 0-0, 0-0 vs. AP Top 25; Ohio State 0-0, 0-0 vs. AP Top 25
Opening Line: Ohio State -49.5, O/U 56.5
Over/Under: 56.5 (O -105, U -115)
FPI Projection Ohio State by 50.5 points with a >99% probability to win game outright

Tennessee State at No. 3 Georgia -46.5
Saturday, 3 p.m., SECN+
Records: Tennessee State 0-1; Georgia 0-0, 0-0 vs. AP Top 25
Opening Line: Georgia -44.5, O/U 56.5
Money line: Tennessee State (+--); Georgia (+--)
Over/Under: 55.5 (O -115, U -105)
FPI Projection Georgia by 61.9 points with a >99% probability to win game outright

Boise State at No. 2 Oregon -24.5
Saturday, 3:30 p.m., CBS
Records: Boise State 0-0, 0-0 vs. AP Top 25; Oregon 0-0, 0-0 vs. AP Top 25
Opening Line: Oregon -24.5, O/U 52.5
Money line: Boise State (+1200); Oregon (-2400)
Over/Under: 51.5 (O -108, U -112)
FPI Projection Oregon by 24.7 points with a 95% probability to win game outright

Texas State at No. 5 Texas -29.5
Saturday, 3:30 p.m., ESPN
Records: Texas State 0-0, 0-0 vs. AP Top 25; Texas 0-0, 0-0 vs. AP Top 25
Opening Line: Texas -30.5, O/U 59.5
Money line: Texas State (+2500); Texas (-9000)
Over/Under: 59.5 (O -108, U -112)
FPI Projection Texas by 35 points with a 98% probability to win game outright

Marshall at No. 18 Penn State -23.5
Saturday, 3:30 p.m., FS1
Records: Marshall 0-0, 0-0 vs. AP Top 25; Penn State 0-0, 0-0 vs. AP Top 25
Opening Line: Penn State -23.5, O/U 54.5
Money line: Marshall (+1400); Penn State (-3200)
Over/Under: 52.5 (O -102, U -118)
FPI Projection Penn State by 25.9 points with a 95% probability to win game outright

Furman at No. 20 Tennessee -46.5
Saturday, 3:30 p.m., SECN+
Records: Furman 1-0; Tennessee 0-0, 0-0 vs. AP Top 25
Opening Line: Tennessee -46.5, O/U 66.5
Over/Under: 66.5 (O -112, U -108)
FPI Projection Tennessee by 46.6 points with a >99% probability to win game outright

Northern Illinois at No. 22 Iowa -31.5
Saturday, 4:15 p.m., BTN
Records: Northern Illinois 0-0, 0-0 vs. AP Top 25; Iowa 0-0, 0-0 vs. AP Top 25
Opening Line: Iowa -29.5, O/U 43.5
Money line: Northern Illinois (+5000); Iowa (-100000)
Over/Under: 44.5 (O -110, U -110)
FPI Projection Iowa by 28.5 points with a 97% probability to win game outright

Missouri State at No. 8 Texas A&M -40.5
Saturday, 7 p.m., ESPN
Records: Missouri State 0-0, 0-0 vs. AP Top 25; Texas A&M 0-0, 0-0 vs. AP Top 25
Opening Line: Texas A&M -38.5, O/U 52.5
Over/Under: 53.5 (O -112, U -108)
FPI Projection Texas A&M by 34.4 points with a 98% probability to win game outright

Abilene Christian at No. 12 Texas Tech -42.5
Saturday, 7 p.m., FS1
Records: Abilene Christian 0-1; Texas Tech 0-0, 0-0 vs. AP Top 25
Opening Line: Texas Tech -42.5, O/U 59.5
Over/Under: 59.5 (O -105, U -115)
FPI Projection Texas Tech by 40.6 points with a >99% probability to win game outright

Clemson at No. 11 LSU -10
Saturday, 7:30 p.m., ABC
Records: Clemson 0-0, 0-0 vs. AP Top 25; LSU 0-0, 0-0 vs. AP Top 25
Opening Line: LSU -10.5, O/U 50.5
Money line: Clemson (+295); LSU (-375)
Over/Under: 50.5 (O -112, U -108)
FPI Projection LSU by 9.5 points with a 75% probability to win game outright

Western Michigan at No. 16 Michigan -27.5
Saturday, 7:30 p.m., NBC
Records: Western Michigan 0-0, 0-0 vs. AP Top 25; Michigan 0-0, 0-0 vs. AP Top 25
Opening Line: Michigan -26.5, O/U 47.5
Money line: Western Michigan (+2000); Michigan (-6500)
Over/Under: 49.5 (O -112, U -108)
FPI Projection Michigan by 23 points with a 94% probability to win game outright

Utah Tech at No. 14 BYU -51.5
Saturday, 8 p.m., ESPN+
Records: Utah Tech 0-1; BYU 0-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened BYU -47.5, O/U 54.5
Over/Under: 61.5 (O -110, U -110)
FPI Projection BYU by 49.4 points with a >99% probability to win game outright

Washington State at No. 17 Washington -23.5
Sunday, 4 p.m., NBC
Records: Washington State 0-0, 0-0 vs. AP Top 25; Washington 0-0, 0-0 vs. AP Top 25
Opening Line: Washington -21.5, O/U 50.5
Money line: Washington State (+1100); Washington (-2100)
Over/Under: 51.5 (O -105, U -115)
FPI Projection Washington by 16.9 points with a 88% probability to win game outright

Wisconsin at No. 4 Notre Dame -20.5
Sunday, 7:30 p.m., NBC
Records: Wisconsin 0-0, 0-0 vs. AP Top 25; Notre Dame 0-0, 0-0 vs. AP Top 25
Opening Line: Notre Dame -20.5, O/U 47.5
Money line: Wisconsin (+950); Notre Dame (-1650)
Over/Under: 46.5 (O -112, U -108)
FPI Projection Notre Dame by 23.9 points with a 94% probability to win game outright

No. 24 Louisville at No. 9 Ole Miss -6.5
Sunday, 7:30 p.m., ABC
Records: Louisville 0-0, 0-0 vs. AP Top 25; Ole Miss 0-0, 0-0 vs. AP Top 25
Opening Line: Ole Miss -7, O/U 53.5
Money line: Louisville (+220); Ole Miss (-270)
Over/Under: 55.5 (O -105, U -115)
FPI Projection Ole Miss by 8.8 points with a 74% probability to win game outright

No. 19 SMU -3 at Florida State
Monday, 7:30 p.m., ESPN
Records: SMU 0-0, 0-0 vs. AP Top 25; Florida State 1-0, 0-0 vs. AP Top 25
Opening Line: SMU -2.5, O/U 52.5
Money line: SMU (-148); Florida State (+124)
Over/Under: 53.5 (O -110, U -110)
FPI Projection SMU by 1.9 points with a 56% probability to win game outright
