Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. All fantasy advice is geared toward ESPN 10-team leagues with standard scoring.
Note: All information is accurate as of the time of publication. For updates, as well as any breaking news that might impact today's MLB slate, be sure to check out the latest fantasy baseball buzz.
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ESPN's 2026 Draft Guide | Betting notes for Wednesday
Pitchers to stream on Wednesday
For the past two seasons, Andrew Abbott has fared better at home at the Great American Ball Park than on the road. Pitchers enjoy an intrinsic 5% home-field advantage, but this isn't sufficient to balance the advantage Abbott's home venue gives to hitters. His home success has been impressive; however, albeit in a small sample, the Cincinnati Reds lefty has struggled at home while excelling on the road. While some of this may be variance, facing the New York Mets at Citi Field will likely serve to further widen Abbott's splits.
Michael Soroka has recorded a quality start in three of his last four outings, posting a 1.48 ERA and 1.03 WHIP over that span. His 18.5% K-BB% is pacing toward a career best. He's in a great spot to stay on a roll with the Arizona Diamondbacks visiting the San Francisco Giants in pitcher-friendly Oracle Park. Though they've been better lately, for the season the Giants sport the fourth-lowest home wOBA facing right-handers.
Casey Mize has two quality starts since returning from the IL due to an adductor strain. Before the injury, two of his three prior efforts were also quality starts. He's not racking up strikeouts, but after surrendering a homer in each of his first two starts, Mize has not yielded another long ball. He's due for some regression on his 3.5% HR/FB, but his above-average control will minimize the damage. Wednesday presents a challenging home matchup when the Detroit Tigers welcome the Los Angeles Angels to Comerica Park. Surprisingly, the visitors have been productive on the road, but Mize is locked in.
Hitters to stream on Wednesday
The Pittsburgh Pirates have recorded the third-highest home wOBA versus right-handed pitching. On Wednesday, they entertain Jameson Taillon and the Chicago Cubs. Taillon spent the first four seasons of his career in Steel City. Even since leaving to pitch for the New York Yankees and Cubs, Taillon's 1.51 HR/9 is the highest in the league, and this season it is a whopping 2.77 in 55 1/3 innings. The Pirates lack sluggers, but Spencer Horwitz, Nick Gonzales, Jhostynxon Garcia and Esmerlyn Valdez can benefit from Taillon's generosity.
The Cleveland Guardians host Miles Mikolas and the Washington Nationals. The veteran righty sports one of the highest ERAs among starting pitchers, in part due to a bloated home run rate. He doesn't miss many bats, which feeds into the Guardians' approach. Travis Bazzana, Kyle Manzardo, Daniel Schneemann and Angel Martinez line up for productive games.
