Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. All fantasy advice is geared toward ESPN 10-team leagues with standard scoring.
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Other resources: RP depth chart | 2026 Rankings
ESPN's 2026 Player Rater | Betting notes for Wednesday
Pitchers to stream on Wednesday
Over his last five outings, Ryne Nelson completed seven innings four times, falling one out short in another. In that six-game span, he has posted a 3.07 ERA and 0.98 WHIP, albeit with only 27 punchouts in 41 frames. However, his pitch efficiency allowed him go deep into games, and innings are integral to points-league scoring.
At some point, Reid Detmers might begin to waver after spending last season as a reliever and as the innings mount, but so far, he's showing the Los Angeles Angels were wise to move him back into the starting rotation. He recorded a 1.89 ERA and 0.68 WHIP over his last three efforts with 27 strikeouts and just five walks over 19 stanzas. Next up is a home date with the Houston Astros.
Over his previous three outings, Foster Griffin has yielded only four earned runs in 16 innings, but each was courtesy of a solo home run. He fanned 15 with just three walks in that span. The Washington Nationals visit the San Francisco Giants in Oracle Park. In part due to the venue, the Giants sport the second-lowest home run rate at home, with only the Boston Red Sox having a lower rate.
Shota Imanaga is rostered in almost 80% of ESPN leagues, precluding him from streaming status. However, he's set to take the bump for the Chicago Cubs in a road matchup against the Colorado Rockies, and the rule of thumb is avoiding all but elite pitchers in Coors Field. Imanaga isn't elite, and he has surrendered 12 homers over his last four starts, covering 21 2/3 innings. At Coors Field, however, the Rockies strike out at a league-high 28.1% clip against lefties, fueling the fifth-worst home wOBA facing southpaws.
