San Francisco 49ers @ Buffalo Bills

San Francisco 49ers49ersSF

1-5, 0-3 Away

16

1-5, 0-3 Away

Final

	1	2	3	4	T
49ers SF	3	10	0	3	16
Bills BUF	7	10	7	21	45

BUF

Buffalo BillsBillsBUF

4-2, 2-1 Home

45

4-2, 2-1 Home

Game Information

Orchard Park, NY

Highmark Stadium (Old)

FOX

Line Judge:Gary Arthur

Back Judge:Dino Paganelli

Umpire:Bill Schuster

Referee:Gene Steratore

Field Judge:Mike Weatherford

Side Judge:Bob Waggoner

Down Judge:Ed Walker

National Football Conference

NFC West	W	L	T	PCT	PF	PA
San Francisco	1	0	0	1.000	27	7
Arizona	1	0	0	1.000	26	14
Seattle	1	0	0	1.000	13	10
Los Angeles	0	1	0	.000	7	27

American Football Conference

AFC East	W	L	T	PCT	PF	PA
Buffalo	1	0	0	1.000	36	31
New York	1	0	0	1.000	23	10
Miami	0	1	0	.000	13	27
New England	0	1	0	.000	10	13

NFL News

NFL Week 1: Takeaways, questions, fantasy spin for Sunday games

Our NFL Nation reporters react to all the action, answering the biggest questions coming out of each Sunday game. Here's what we learned from Week 1.

6h

Giants jab at Cowboys following SNF victory tops NFL Week 1 trolls

Early season rust didn't apply to teams around the NFL trolling their opponents after a victory.

6h

Week 1 winners and losers: Caleb Williams and Josh Allen dominate; Ja'Marr Chase disappoints

Caleb Williams, Josh Allen and Trevor Lawrence came up big in Week 1, while Ja'Marr Chase, Drake London and Colston Loveland had very quiet days.

6h

ESPN

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Call 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in ONT. Eligibility restrictions apply. Terms: draftkings.com/sportsbook. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL.

Copyright: © 2026 ESPN Enterprises, LLC. All rights reserved.

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