League Two side Fleetwood Town will host Arsenal in the fourth round of the Carabao Cup, while Liverpool will host Chelsea.
Fleetwood, who are seventh in League Two and beat Championship side Sheffield United in the third round, will take on the Premier League champions for a place in the quarterfinals.
"It's amazing for the club to welcome the best team in the country and one of the best teams in Europe to Highbury," Fleetwood head coach Matt Lawlor said.
"It will be an amazing occasion for the club. To pit your wits against the best team in the country will be one of the toughest of tests but one we are looking forward to."
Elsewhere, there are all-Premier League clashes between AFC Bournemouth and Aston Villa, Fulham and Crystal Palace, Sunderland and Brentford, and Newcastle United and Everton.
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Brighton & Hove Albion, who came from two goals down to stun Manchester United in the third round, will face either Manchester City or Norwich.
League One sides Bradford and Peterborough will also go head-to-head.
All fourth-round matches will be held in the week commencing Oct. 26.
Information from PA contributed to this report.
