| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Drake Maye |
1. Drake Maye, QB | NE | L 30-24 at CHI | 24 | 31 | 321 | 2 | 1 | 2 | 0 | 117.8 |
| 2. Caleb Williams, QB | CHI | W 30-24 vs. NE | 22 | 33 | 308 | 2 | 0 | 3 | 0 | 116.7 | |
| 3. Deshaun Watson, QB | CLE | W 27-24 at TEN | 25 | 36 | 308 | 0 | 1 | 1 | 0 | 84.0 | |
| 4. Jared Goff, QB | DET | W 20-17 vs. GB | 22 | 32 | 303 | 2 | 0 | 1 | 1 | 119.7 | |
| 5. Tyler Huntley, QB | BAL | L 35-13 vs. CIN | 23 | 34 | 298 | 1 | 1 | 4 | 0 | 92.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Javonte Williams |
1. Javonte Williams, RB | DAL | W 38-21 at PHI | 25 | 155 | 6.2 | 1 | 34 | 0 | |
| 2. Tony Pollard, RB | TEN | L 27-24 vs. CLE | 25 | 129 | 5.2 | 3 | 36 | 0 | ||
| 3. Cam Skattebo, RB | NYG | W 27-21 at HOU | 17 | 124 | 7.3 | 1 | 42 | 0 | ||
| 4. Jahmyr Gibbs, RB | DET | W 20-17 vs. GB | 29 | 116 | 4.0 | 0 | 15 | 1 | ||
| 5. Bucky Irving, RB | TB | W 43-13 at CAR | 24 | 106 | 4.4 | 2 | 15 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Amon-Ra St. Brown |
1. Amon-Ra St. Brown, WR | DET | W 20-17 vs. GB | 9 | 153 | 17.0 | 0 | 40 | 0 | |
| 2. Jaxon Smith-Njigba, WR | SEA | W 20-3 vs. KC | 9 | 150 | 16.7 | 1 | 33 | 0 | ||
| 3. Tee Higgins, WR | CIN | W 35-13 at BAL | 6 | 148 | 24.7 | 1 | 44 | 0 | ||
| 4. Zay Flowers, WR | BAL | L 35-13 vs. CIN | 8 | 137 | 17.1 | 1 | 48 | 0 | ||
| 5. Luther Burden III, WR | CHI | W 30-24 vs. NE | 4 | 130 | 32.5 | 1 | 58 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Alex Singleton |
1. Alex Singleton, LB | DEN | W 30-16 at ARI | 12 | 7 | 19 | 1.0 | 0 | 0 | 0 |
| 2. Kevin Winston Jr., S | TEN | L 27-24 vs. CLE | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Christian Elliss, LB | NE | L 30-24 at CHI | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Fred Warner, LB | SF | L 29-20 at ATL | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Blake Cashman, LB | MIN | W 16-10 vs. IND | 8 | 4 | 12 | 2.0 | 0 | 0 | 0 | |
