| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Brock Purdy |
1. Brock Purdy, QB | SF | W 27-7 at LAR | 25 | 34 | 205 | 3 | 1 | 0 | 0 | 105.6 |
| 2. Drew Lock, QB | SEA | W 13-10 vs. NE | 16 | 22 | 187 | 1 | 0 | 1 | 0 | 113.3 | |
| 3. Drake Maye, QB | NE | L 13-10 at SEA | 23 | 33 | 178 | 1 | 3 | 3 | 0 | 54.9 | |
| 4. Matthew Stafford, QB | LAR | L 27-7 vs. SF | 15 | 25 | 155 | 0 | 1 | 0 | 0 | 61.3 | |
| 5. Sam Darnold, QB | SEA | W 13-10 vs. NE | 1 | 2 | 13 | 0 | 0 | 1 | 0 | 70.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Christian McCaffrey |
1. Christian McCaffrey, RB | SF | W 27-7 at LAR | 10 | 68 | 6.8 | 0 | 16 | 0 | |
| 2. Kaelon Black, RB | SF | W 27-7 at LAR | 14 | 65 | 4.6 | 0 | 14 | 0 | ||
| 3. Blake Corum, RB | LAR | L 27-7 vs. SF | 10 | 54 | 5.4 | 0 | 13 | 0 | ||
| 4. Jadarian Price, RB | SEA | W 13-10 vs. NE | 10 | 52 | 5.2 | 0 | 13 | 0 | ||
| 5. Rhamondre Stevenson, RB | NE | L 13-10 at SEA | 18 | 51 | 2.8 | 0 | 12 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Jaxon Smith-Njigba |
1. Jaxon Smith-Njigba, WR | SEA | W 13-10 vs. NE | 8 | 122 | 15.3 | 1 | 45 | 0 | |
| 2. Puka Nacua, WR | LAR | L 27-7 vs. SF | 5 | 74 | 14.8 | 0 | 41 | 0 | ||
| 3. Mack Hollins, WR | NE | L 13-10 at SEA | 4 | 51 | 12.8 | 0 | 19 | 0 | ||
| 4. Demarcus Robinson, WR | SF | W 27-7 at LAR | 2 | 50 | 25.0 | 1 | 39 | 0 | ||
| 5. Mike Evans, WR | SF | W 27-7 at LAR | 6 | 49 | 8.2 | 1 | 13 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Ernest Jones IV |
1. Ernest Jones IV, LB | SEA | W 13-10 vs. NE | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Fred Warner, LB | SF | W 27-7 at LAR | 5 | 6 | 11 | 0.0 | 1 | 0 | 0 | |
| 3. Quentin Lake, S | LAR | L 27-7 vs. SF | 7 | 3 | 10 | 0.0 | 0 | 1 | 0 | |
| 4. Marques Sigle, S | SF | W 27-7 at LAR | 4 | 5 | 9 | 0.0 | 0 | 0 | 0 | |
| 5. Drake Thomas, LB | SEA | W 13-10 vs. NE | 3 | 6 | 9 | 1.0 | 0 | 0 | 0 | |
