The Duke Blue Devils are favored to cut down the nets in Minneapolis, but there are plenty of games to play before the Final Four.
Here are the betting lines for every first-round game from the Westgate Las Vegas SuperBook.
For help with every selection, be sure to check out PickCenter, which has projections for every NCAA tournament game.
Lines as of Sunday at 8:30 p.m. ET.
East Region
No. 8 VCU (-1.5) vs. No. 9 UCF
No. 5 Mississippi State (-7.5) vs. No. 12 Liberty
No. 4 Virginia Tech (-10) vs. No. 13 St. Louis
No. 3 LSU (-8) vs. Yale
No. 7 Louisville (-4.5) vs. No. 10 Minnesota
No. 2 Michigan State (-19.5) vs. No. 15 Bradley
West Region
No. 8 Syracuse (-2) vs. No. 9 Baylor
No. 5 Marquette (-4) vs. No. 12 Murray State
No. 4 Florida State (-11) vs. No. 13 Vermont
No. 3 Texas Tech (-15) vs. No. 14 Northern Kentucky
No. 7 Nevada (-2.5) vs. No. 10 Florida
No. 2 Michigan (-16) vs. No. 15 Montana
South Region
No. 1 Virginia (-24) vs. No. 16 Gardner-Webb
No. 8 Ole Miss (-2) vs. No. 9 Oklahoma
No. 5 Wisconsin (-1.5) vs. No. 12 Oregon
No. 4 Kansas State (-5.5) vs. No. 13 UC Irvine
No. 3 Purdue (-12) vs. No. 14 Old Dominion
No. 6 Villanova (-5) vs. No. 11 Saint Mary's
No. 7 Cincinnati (-4) vs. No. 10 Iowa
No. 2 Tennessee (-17.5) vs. No. 15 Colgate
Midwest Region
No. 1 North Carolina (-25) vs. No. 16 Iona
No. 8 Utah State (-3.5) vs. No. 9 Washington
No. 5 Auburn (-7.5) vs. No. 12 New Mexico State
No. 4 Kansas (-8.5) vs. No. 13 Northeastern
No. 3 Houston (-12) vs. No. 14 Georgia State
No. 6 Iowa State (-6) vs. No. 11 Ohio State
No. 7 Wofford (-3) vs. No. 10 Seton Hall
No. 2 Kentucky (-22) vs. No. 15 Abilene Christian
